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Spotlight on Microbial & Cellular Frontiers
Rohita Biswas,
Cinthya Souza Simas,
Sara Tóth Martínez,
María Belén Moyano,
Felicitas S. Holzer,
Gerhard G. Steinmann,
Roland Mertelsmann
Affiliation: Journal of Science, Humanities and Arts (JOSHA), Freiburg im Breisgau, Germany
Keywords: Single-cell Transcriptomics; Therapeutic Colonization; Heme Piracy; Transcriptional Homeostasis; MCL-1 Metabolism; Platelet Biosensors.
Categories: News and Views
DOI: 10.17160/josha.13.2.1133
Languages: English
This collection brings together six research articles that illuminate the molecular and cellular mechanisms shaping microbial communities, host–pathogen interactions, and fundamental cell biology. It covers the application of single-cell transcriptomics to uncover functional diversity within microbiomes, the engineering of controllable gut bacteria for therapeutic colonization, and the design of AI-guided proteins that block iron acquisition by pathogenic E. coli. Additional studies explore a universal homeostatic mechanism governing transcription factor activity, the metabolic roles of the anti-apoptotic protein MCL-1 beyond cell death regulation, and the unexpected capacity of platelets to sequester circulating cell-free DNA with implications for cancer diagnostics and prenatal testing. Together, these findings advance understanding of gene regulation, microbial ecology, and translational biotechnology.